Shvets V. Age peculiarities of myocardium energy metabolism and theirs interaction with modulation of free radical processes during stress

The object of study - energy metabolism, free radical oxidation, enzyme defense system against oxidative stress of myocardium of adult and old immobilized rats. The aim of study - investigation of energy metabolism and its interaction with modulation of free radical oxidation in the heart of adult and old rats during immobilization stress. Methods - spectrophotometry, spectrofluorimetry, chemiluminescence analysis, ion-exchange chromatography, differential centrifugation. Theoretical and practical results, newness - it is established that the level of energy supply for myocardium is reduced under the immobilization stress. Energy metabolism disorder due to stimulation of free-radical processes, in the conditions of lowing carbonyl product utilization in the heart, plays an important role in this process. Reduction of energy provision level of the myocardium during stress is accompanied by shifts, which limit the value of creatine phosphate as a energy buffer, and by growth of intensity of anaerobic glycolysis, in a greater degree for old rats. Unlike the adult animals the redox processes in myocardium mitochondria are not limited, that in conditions of arising tissue hypoxia during stress reflects age-dependent desadaptation of energy metabolism. The sphere of application - research of age-related heart pathology mechanisms