Ilchenko S. Age pathogenetic aspects of development and transformation of recurrent and chronic bronchitis in children and adolescents.

Work is devoted to solving urgent problems - improve early diagnosis, prediction and prevention of transformation of recurrent bronchitis of children in chronic bronchitis of adolescents and chronic obstructive pulmonary disease of adults. The results of the research, including experimental, presented the concept on the role of specific risk factors (including bronchopulmonary dysplasia, active and passive smoking, the propensity to pneumofibrosis, energy - deficit states, disbiotical disorders of microflora of medium and lower respiratory tract, dyskinesia of respiratory muscles) in the development of chronic inflammation in bronchus and formation of chronic bronchitis due to violation of the metabolic and drainage functions of respiratory system. Given this concept, the effective diagnostic methods and prevention circuitry of irreversible changes in bronchus with the appointment of preparations with antioxidative and metabolic activities were proposed.