Ostash B. Combinatorial biosynthesis of novel antibiotics in actinomycetes

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0512U000852

Thesis Registration Form

0512U000852.pdf

Applicant for

Specialization

  • 03.00.22 - Молекулярна генетика

27-11-2012

Specialized Academic Board

Д 26.237.01

Institute of Molecular Biology and Genetics of NAS of Ukraine

Essay

This work deals with the problem of development of novel antibiotics via genetic сonstruction of secondary metabolism (SM) in actinomycetes. It is aimed to reveal main rules of combinatorial biosynthesis from analysis of production of landomycins, pacidamycins and moenomycins. Methods of molecular genetics, genomics, bioinformatics and chemistry were used. Universality of translational regulation of SM, integration of synthesis and export steps, modularity of function of SM are shown. This is first case of biotechnological generation of novel pacidamycins and moenomycins. Areas of application - biotechnology, pharmacy.

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Files

aref-ostash27nov12.pdf

diser-ostash27nov12.pdf

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