Marushko R. Prognostication, diagnosis, prevention and treatment of bowel diseases in infants.

The dissertation is dedicated in solving actual scientific problems to enhance efficiency of diagnostics, prevention and treatment in infants with functional and chronic inflammatory bowel diseases. The paper presents data on study of characteristics of clinical manifestation of functional intestinal disorders and indeterminate colitis. There were identified major risk factors and created a mathematical model in predicting of the development of these diseases in infants. It was performed in-depth study of pathogenetic mechanisms of functional and inflammatory bowel diseases in infants. Identified immunological changes, as evidenced by appropriate cytokine profile, disorders of the metabolism of fatty acids, decrease cytoprotective properties of intestinal mucosa and intestinal microbiota imbalance. Determined that the deficiency of omega-3 PUFAs in the diet of women during pregnancy and breastfeeding had negative impact on lactation in women and health of children at early age. The necessity to include omega-3 PUFAs are recommended not only for prevention, but also in the complex therapy of functional and inflammatory bowel disease in infants. Substantiated and implemented alimentary and pharmacological correction of treatment of functional and inflammatory bowel diseases in infants using functional foods, medicine and diets showed sufficient clinical efficacy. Advanced therapy contributed to more rapidly improvement of clinical symptoms, increased the number of excellent treatment results and reduced the frequency of relapses of functional and inflammatory bowel diseases.