Korol L. Mechanisms of oxidative stress in inflammatory processes in the kidneys and ways to correct

The results of the studing confirmed that the intensification of OS is the result of violations of oxidant-antioxidant balance (in bacterial-induced inflammation of the key influential factor is the reduction of SH-groups level and in immune-induced inflammation - reduction of ceruloplasmin serum level), which correlated with increasing levels of cytokines IL-1?, -4, -6, -8, -17, -23, TFR?, TNF?, MCP1, inflammatory proteins (C-reactive protein, fibronectin, cystatine C) and markers of kidney damage. The highest intensity of OS and reduction in the content of transferrin, ceruloplasmin and SH-groups in serum, correlated with levels of specific inflammatory proteins and the activity of renal enzymes in blood and urine and increase concentrations of IL-1?, -8, and TFR?, were observed in the case of recurrent pyelonephritis. The development of bacterial-induced inflammation of the kidneys associated with increase in the excretion of malondialdehyde in the urine and increase in markers of kidney damage, and a decrease in the content of SH-groups correlated with increasing activity of L- arginine:glycine amidinotransferase and the content of C-reactive protein, fibronectin and cystathin in urine. Results of the study proved crucial role of OS in pyelonephritis recurrence and the formation of kidney fibrosis structures and established correlative relationship between the intensity of OS and angiotensin-converting enzyme activity of blood in patients with pyelonephritis.