Boichenko A. Cardiovascular disorders of the perinatal period: risks and mechanisms of development, early diagnosis, prognosis of the course.

The dissertation deals with optimization of early diagnosis, prognosis of the course of cardiovascular disorders of the perinatal period in newborns. The study allowed to determine the criteria for diagnosing cardiovascular disorders in newborns from perinatal risk groups based on the results of spectral and tissue Doppler imaging to identify normative morphometric indices of cardiovascular system in newborns in the neonatal period and to assess the state of the cardiovascular system in prospective follow-up at 1, 3, 6, 12 and 18 months of biological age. The expediency of dynamic ultrasonic monitoring of systolic and diastolic functions of the heart ventricles by "double" Doppler method in newborns from perinatal risk groups was studied and substantiated. The normal speed and time parameters of motion of fibrous rings of mitral and tricuspid valves according to tissue Doppler mapping in healthy newborns in the early neonatal period were determined, and criteria for diagnosis of types of diastolic dysfunction were elaborated. Diagnostic criteria for hemodynamically significant open arterial duct in prematurely born children were supplemented. The approach to the diagnosis of cardiovascular disorders in newborns by means of complex assessment of Doppler echocardiography parameters, biochemical data (levels of LDH, GGT) was improved and systematized. The echographic criteria associated with the polymorphism of eNOS, MnSOD2 and ADRB1 were determined. The model of clinical prognosis and stratification of the risk of cardiovascular diseases development in newborns from perinatal risk groups during the first year of life was proposed and scientifically substantiated.