Kykhtenko O. Pathological anatomy of the blood-brain barrier at perinatal hypoxic stress

The work deals with investigation of pathomorphological changes in the blood-brain barrier of the fetuses and newborns exposed to hypoxia of different origin at different terms of the perinatal period. Hypoxia was considered a stress state and, respectively, the pathoanatomical changes in the blood-brain barrier were compared with the level of the morphofunctional activity of stress-organizing and stress-limiting neuroendocrine structures, namely epiphysis of the brain and adrenocorticotropocytes of the hypophysis. The work is based on investigation of archive, section and experimental material. The following methods were used: anthropometry, somatometry, organometry, macroscopy, histology, histochemistry, morphometry, immunohistochemistry, cytophotometry, electronmicroscopy, statistical analysis. The performed complex morphology investigation allows to formulate the concept of the unfavorable outcome at various in etiology and severity hypoxic damages as a failure of forming adaptation-compensation processes, regulated and determined by the potential of stress-organizing endocrine glands, which was demonstrated by the example of the brain epiphysis and hyphophyseal adrenocorticotropocytes. At disorders in the blood-brain barrier permeability with development of vasogenic and cytotoxic edema of the brain resulting in lethal outcome, exhaustion of morphofunctional recourses of the brain epiphysis and adrenocorticotropocytes of the hypophysis up to development of massive cell death in them can be the morphological markers of decomposition phase.