Bobyr V. Enteroviruses in structure of disbiotic disorders

In the dissertation based on the results of paraclinical and experimental research a theoretical generalization is made and an important scientific problem - elucidation of the enteroviruses role in the structure of intestinal microbiome disorders - is solved. On the basis of the conducted researches new approaches to correction of the normal intestinal microflora composition taking into account the viral factor are scientifically substantiated. Based on virological and molecular genetic studies of fecal masses of healthy individuals and people with dysbiosis the regular presence of viral agents (enteroviruses, noroviruses, bacteriophages) was established. In the experiment with mice on the example of enteroviruses the interaction of virome and bacterial intestinal microbiome in dysbiosis was proved. The scientific hypothesis about the ability of enteroviruses to initiate pronounced apoptotic processes in the small intestine and generalized necrotic changes in the liver was formulated. In the process of modeling of viral and bacterial infections on the dysbiosis background, the effectiveness of prophylactic use of enterosorbents was substantiated. The pronounced hepatoprotective property of bentonite based sorbent, aimed at preserving the ultrastructural organization of the liver, was established, that was confirmed by electron microscopic studies.