Vlasova O. Clinical and pathogenetic significance of environmental factors for the formation, course and consequences of neonatal sepsis: improvement of the diagnosis, treatment and prevention measures

Object - neonatal sepsis in children whose parents live permanently in conditions of contrasting environmental characteristics; goal - to improve the system of diagnosis, prognosis, treatment of neonatal sepsis in children from environmentally unfavorable areas of Western Ukraine on the basis of studying the impact of environmental factors on fetal development and the nature of the disease in newborns; methods - physical, general clinical, bacteriological, assessment of acid-base status and gas composition of blood, immunological, cytological, biochemical, statistical; results - for the first time an environmental risk factor is proposed to assess the complex impact of low-intensity environmental factors on the health of pregnant women and newborns; it has been proven that living of parents in conditions of ecological distress increases the risk of developing structural congenital malformations in their children by 1.6 times and cytogenetic disorders; for the first time, data on the more severe course of sepsis of newborns whose parents lived in places at high risk of exposure to low-intensity ecostimuli; it is established that treatment of sepsis of newborns from the zone of high ecological risk requires longer and more intensive therapy; developed and implemented a constellation diagnostic system to identify variants of sepsis of newborns whose parents lived in areas of increased risk of low-intensity environmental stimuli, and proposed an algorithm for the initial stage of management of sepsis in newborns whose parents lived in places with different characteristics.