The dissertation is devoted to solving an important scientific and technical problem related to the need to expand the range of functional materials based on polysaccharides for pharmacotherapeutic purposes with a set of improved operational properties which could ensure bioavailability and prolonged action of the drug. The mechanism of physicochemical transformations in technologies of obtaining functional materials on the basis of polysaccharides is found and the influence on formation of a complex of properties of the received materials (films, nonwoven materials) for pharmacotherapeutic purposes is defined. It was found that γ-irradiation of cellulose in the range of absorption doses D ≈ 10-20 kGy, provides a predictable physicochemical modification, accompanied by the production of monodisperse cellulose. Changing the degree of polymerization and polydispersity of cellulose of different origin when irradiated depending on the absorption doses allows you to adjust these indicators in a wide range and guaranteed to obtain cellulose esters with high solubility in water. The effect of the influence of the concentration of sodium hydroxide in the reaction mass (27-31%) during mercerization of cellulose is found, which provides water-soluble CMC with a relatively low degree of substitution of 40-45. It has been found that carboxymethylation leads to changes in the structural ordering of cellulose at the supramolecular level, in particular, there is a decrease in the proportion of crystallites in the polymer volume by 35%, which is typical for all cellulosic materials treated with high concentration alkali. The dependence of the viscosity of aqueous solutions of CMC, CMS on their concentration and degree of polymerization and temperature is found and mathematically described. The mathematical equations presented in the work can be recommended for calculations and creation of computer programs of automated control of technological processes, which will help to reduce the duration of the technological cycle at the stage of production preparation. According to the results of IR spectroscopy, it was found that in the spectra of film and nonwoven materials based on polymer compositions with CMS with the addition of decamethoxine, antiseptics SG and nimesulide, characteristic absorption bands are observed for these APIs, indicating no stable chemical interaction between components. A scientifically substantiated approach is developed to the introduction of selected bactericidal ingredients into the polymer matrix - QAS of decamethoxine, 6,9-diamino-2-ethoxyacridinium-3-nitroanthranylate (SG 112, SG 418, or SG 155), and the painkiller API ‒ nimesulide. Non-additive effect on the viscosity of the introduction of other polymers based on CMS (PVA, sodium alginate, gelatin) has been found. The peculiarities of API release from films based on CMS compositions with other polymers are found, which depends on the rate of swelling and dissolution of polymers, and is described by the second-order reaction equation. It was found that solutions of compositions based on CMS with the addition of PVA, sodium alginate, gelatin are abnormally viscous structured systems (n <1), characterized by a sufficiently high degree of thixotropic viscosity recovery (85-99 %), which is associated with low structure of the investigated solutions. It is found that the release of decamethoxine into the aqueous phase proceeds by a complex diffusion-kinetic mechanism and the polymer composition of the film significantly affects the release kinetics. It is determined that a prerequisite for efficient electrospinning is the presence of water-soluble synthetic polymers PVA and PVAc in the composition. It is found that the extraction of the jet and fiber formation occurs at an electric field voltage of more than 4 kV/cm, with the electrical conductivity of the solutions in the range (0,568-1,515 Cm/ m), and the addition of decamethoxine, antiseptic SG, dissolution of chitosan and oxidation of starch in lactic and acetic acids improve the process of electrospinning by increasing the electrical conductivity of solutions. It was found that thermal stabilization of samples of nonwoven materials based on PVA and PVAc with the addition of starch and chitosan for 2 hours, improves the resistance of the sample to water, although it impairs the sorption properties. The use of fiber-forming compositions based on PVA and PVAc with the addition of starch, chitosan, gelatin, provides ultra-thin fibers with an average diameter of 0,32, 0,24 and 0,17 μm respectively. It is proved that polymer compositions based on polysaccharides and their derivatives (CMS, chitosan, starch) with the addition of antimicrobial drugs (decamethoxine, 9-aminoacridine derivatives) provide a prolonged antimicrobial effect on fungi.
