Vitruk Y. Optimization of Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Renal Cell Carcinoma

The dissertation presents a scientific justification and a new solution to a problem relevant for modern medicine, in particular oncology and urology – increasing the effectiveness of treatment of patients with locally advanced and metastatic renal cell carcinoma by improving diagnostics and optimizing treatment tactics based on the study of molecular, genetic, anatomical-functional features and systemic changes, development and implementation of a complex approach using neoadjuvant targeted therapy, a new nephrometics system for determining indications for renal resection or nephrectomy and personalized treatment. The work is based on 3 stages, including a retrospective analysis of the pathological material of 175 patients with renal cell carcinoma, and prospective studies involving 247 patients with locally advanced and metastatic renal cell carcinoma (mRCC).