Semenikhina M. "The role of protease-activated receptor 1 in behavioral impairments following status epilepticus"

The aim of the present work was to determine the role of protease-activated receptor 1 (PAR1) in status epilepticus (SE)-induced behavioral comorbidities. Using different approaches to study animal behavior and electrophysiological techniques we studied the effect of PAR1 inhibition on different behavioral measures such as the level of anxiety and emotion excitability, contextual and cued fear learning, spatial learning and sociability; and electrophysiological parameters: synaptic efficacy, short- and long-term plasticity of hippocampal CA3-CA1 synapses. Here we showed that inhibition of PAR1 during epileptogenesis abolished the alteration of the anxiety level and behavioral excitability in rats experiencing SE. We also demonstrated that PAR1 inhibition does not affect social behavior impairment and spatial learning deficits in rat model of SE. Using electrophysiological approaches, we showed that the downregulation PAR1-dependent signaling prevents the alteration of plasticity of hippocampal CA3-CA1 synapses in rats with SE which might represent the cellular correlate of epilepsy-related behavioral deficits.