Kovalenko I. Antimicrobial action of decamethoxine and fluoroquinolones and their effect on the arginase/NO synthase and antioxidant system of blood lymphocytes.

The dissertation is devoted to the study of antimicrobial action of decamethoxine anesthetics and antibiotics of fluoroquinolone series and their effect on arginase/NO synthase and antioxidant system of human blood lymphocytes. It is shown that decamethoxin (DСM) and its dosage form decasan (DS) showed the same microbicidal activity against E. coli museum strains (15.62 μg/ml), C. albicans (16 μg/ml), E. faecalis (0,97 μg/ml), Bас. subtilis (0.24 μg/ml). DS was less microboccidally active against S. aureus (0,48 μg/ml) compare to DMC (0.24 μg/ml). Based on the results of studies, it was established that DCM and DS in different bacteriostatic (MBsC) and bactericidal (MBcC) concentrations significantly affect the adhesive capacity of gram-positive (staphylococci) and gram-negative (Escherichia) bacteria. At the presence of MBsC antiseptics, the percentage of bacterial cells adhesion of staphylococci decreased both in the presence of DCM and in the presence of DS by 58-59 %. MBsC of antibacterial drugs inhibited the adhesion process of Escherichia much more intensively. Thus, the results obtained regarding the action of decamethoxin and fluoroquinolones indicate significant changes in the arginase-NO-synthase and glutathione antioxidant systems of blood lymphocytes, which leads to their imbalance and impaired regulatory role.