Vovk A. The effect of probiotic composition on the course of inflammation in the development of experimental osteoarthritis.

Musculoskeletal disorders are one of the main factors for premature disability in the world, in which osteoarthritis (OA) is the most common disease. OA is associated with disruption of normal repair processes of joint elements, and it leads to the development of osteophytes and fibrosis of joint surfaces, limited motion activity, and acute pain. Modem views on the problem of OA depart from the classical concept of «wear and tear» to the understanding of a wide range of processes that contribute to or inhibit degenerative-dystrophic changes in joint tissues, including inflammation and oxidative stress. The results of recent studies highlight a wide range of biochemical parameters involved in the development of ОА. Most of the signaling pathways of OA are also common to processes associated with the human microbiome, a potent immunomodulatory factor, a source of important signaling molecules, and unique metabolites. In this point of view, the study of the OA-microbiome axis has become relevant, in order to develop therapeutic concepts of microbiome state correction by probiotics (PB), that include in different PB-compositions.