Nehrych O. Diagnosis, treatment and prevention of reproductive health disorders in women with multiple sclerosis.

The dissertation is devoted to reducing the incidence of reproductive health disorders and improving the quality of life of women with multiple sclerosis by improving treatment and prevention measures based on new pathogenesis links of reproductive disorders and clinical, biochemical and hormonal characteristics of patients. A study of 116 patients with multiple sclerosis and 40 women of the control group was performed. The main (I) group consisted of 59 women with multiple sclerosis, which was carried out on the basis of the proposed preventive and curative measures. The comparison group (II) included 57 patients with multiple sclerosis, who were treated according to existing recommendations. The data obtained in the dissertation deepen and expand the current understanding of the relationship between hormonal imbalance, vitamin D deficiency, thyroid pathology with the development of menstrual disorders, sexual dysfunction, and reduced quality of life in women with multiple sclerosis. The importance of extended clinical and hormonal examination in the early stages of multiple sclerosis to prevent reproductive disorders has been proven. The need to improve the algorithm of diagnostic and treatment-and-prophylactic measures to prevent reproductive health disorders in women with multiple sclerosis has been scientifically substantiated. The results of the study serve as a theoretical basis for scientifically sound practical recommendations for the management of women with multiple sclerosis.