Stohnii Y. Limited proteolysis of αC-region of fibrinogen

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0821U100522

Applicant for

Specialization

  • 091 - Біологія. Біологія

29-03-2021

Specialized Academic Board

ДФ 26.001.118

Taras Shevchenko National University of Kyiv

Essay

Dissertation for the degree of Doctor of Philosophy in the field of 09 Biology in the speciality 091-Biology. – Taras Shevchenko National University of Kyiv. Kyiv, 2020. Function of hemostasis consist in the support of the blood flow and the efficient termination of bleeding in the case of vessel wall damage. The main protein of hemostasis is fibrinogen. The damage of vessel wall initiates the cascade of enzymatic reactions resulting in the conversion of soluble fibrinogen into fibrin. Fibrin during the self-assembly forms the three-dimension core of blood clot, thus preventing the blood loss. The disorders in blood hemostasis functioning can cause the various pathologies. That is why the investigations of potential ways for the regulation of blood coagulation components is on time.

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