Vilenskyi Y. Features of local immunity of the upper respiratory tract in children with asthma and allergic rhinitis, and correction of its disorders

The dissertation is devoted to the problem of improving the prevention of acute respiratory viral infections and related exacerbations of bronchial asthma and allergic rhinitis in children based on the study of antimicrobial peptides HβD-2 and hCAP18 / LL-37 in nasopharyngeal aspirant and clinical use. containing a strain of LGG, in this group of patients. Modern laboratory methods are used in the work to assess the state of mucosal anti-infective protection of the mucous membranes of the upper respiratory tract in children with bronchial asthma and allergic rhinitis. The data analysis used a sufficient amount of data, which was processed using appropriate statistical methods. The main scientific results. Decreased antimicrobial peptides in nasopharyngeal aspirate in children with allergic respiratory disease have been shown to be associated with an increase in the frequency and prolongation of the mean duration of a single episode of URTI in children with bronchial asthma and allergic rhinitis. Concentrations of antimicrobial peptides in nasopharyngeal aspirate in children with bronchial asthma and allergic rhinitis have been shown to be inversely related to the severity of allergic diseases and lack of symptom control. The relationship between antimicrobial peptide concentrations in nasopharyngeal aspirate in children with bronchial asthma and allergic rhinitis and exogenous modifiable factors has been demonstrated. The expediency, efficiency and safety of probiotic preparation containing LGG in children with bronchial asthma and allergic rhinitis for the prevention of URTI have been substantiated. Scientific novelty and practical significance. Decreased antimicrobial peptides in nasopharyngeal aspirate in children with allergic respiratory disease have been shown to be associated with an increase in the frequency and prolongation of the mean duration of a single episode of URTI in children with asthma and allergic rhinitis. The introduction of a prophylactic algorithm using a drug containing LGG has led to improved control of the underlying disease and reduced the incidence of acute respiratory infections in children with asthma and allergic rhinitis.