Velihina Y. Synthesis and properties of new oxazolo[4,5-d]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines

New oxazolo[4,5-d]pyrimidine and pyrazolo[1,5-a][1,3,5]triazine. Organic synthesis; IR and NMR spectroscopy, chromato-mass spectrometry, X-ray diffraction analysis. The range of new oxazolo[4,5-d]pyrimidine derivatives has been expanded to 35 compounds and a structure-activity relationship has been established in a number of these substances. For the first time, the Suzuki-Miyaura approach was used to functionalize these substances. The possible mechanism of anticancer action of oxazolo[4,5-d]pyrimidine derivatives was studied for the first time and a new selective inhibitor of the long adenosine kinase isoform was found. The interaction of 2-acylamino-3,3-dichloro-acrylonitriles with 5-amino¬pyrazoles was studied for the first time and previously unknown derivatives of 2-dichloromethylpyrazolo[1,5-a][1,3,5]triazine were synthesized. For the first time their anticancer, antiviral and vasodilatory activity was studied and the regularities of "structure-activity" were found. Among them were found a number of anticancer agents and a substance with antiviral potential against BK virus. Scope - bioorganic chemistry.