Polishchuk A. Molecular genetic markers of myocardial hypertrophy in athletes specializing in endurance sports

The thesis is devoted to the study of the role of gene polypolymorphisms and long non-coding RNA in molecular genetic mechanisms of myocardial adaptation to long intensive physical exercise, to establish molecular genetic markers of predisposition to the development of myocardial hypertrophy. The DNA genotyping of highly qualified athletes was performed by real-time polymerase chain reaction and the frequency of allelic variants of candidate genes occurrence in the specified sample was determined. The results allowed for the first time to develop a method for predicting athletes myocardial hypertrophy development, depending on gene polymorphisms (COL12A1, PPARA, PPARG and UCP2) and obtained patent № 141030 "Method for predicting the athletes myocardial hypertrophy development depending on gene polymorphisms". This makes it possible to conduct early non-invasive diagnosis of pathological conditions of the athletes heart specializing in endurance sports.