Franchuk U. Peculiarity of pregnancy with a high risk of late preeclampsia associated with metabolic syndrome

The dissertation research generalizes and solves in a new way prevention and treatment of women with high risk developing preeclampsia associated with metabolic syndrome by improving and modifying treatment methods: L-arginine, calcium carbonate, magnesium sulfate, acetylsalicylic acid and vitamin D. Scientific data on the peculiarities of pregnancy and childbirth in women complicated by preeclampsia associated with metabolic syndrome have been expanded. It is proved that the course of pregnancy and childbirth was more favorable with the proposed modified treatment than with only protocol treatment. Scientific concepts for the predictors of the development of preeclampsia associated with metabolic syndrome have been expanded (more common with increasing age of patients, increasing body mass index). Significant correlations between vitamin D deficiency, inhibin A and their impact on the development of preeclampsia have been clarified. Scientific data on the state of lipid profile in patients with progressive preeclampsia have been added. Significant correlations have been established between inhibin A levels and the occurrence of preeclampsia. Analysis of the data shows that at inhibin A values >250 ng/l the risk of preeclampsia increases and at values <190 ng/l – decreases. According to our results, it is reasonable to prescribe vitamin D (2000 IU) from 16–18 weeks of pregnancy, which leads to more favorable course of pregnancy and childbirth. A trial for this modified treatment in pregnant women with preeclampsia associated with metabolic syndrome was observed. Efficacy of modified therapy (L-arginine, calcium carbonate, magnesium sulfate and acetylsalicylic acid + vitamin D) on the manifestations of preeclampsia in women with metabolic disorders has been proven. The obtained data scientifically substantiate the mathematical prediction of preeclampsia associated with metabolic syndrome (probability of prediction 98,3 %).