Khutorianskyi A. Synthesis of novel derivatives of 1,2-azoles.

This thesis is devoted to the development of synthetic approaches to functionalized derivatives of (fluoroalkyl)-substituted isoxazoles and pyrazoles. These heterocyclic compounds could be of interest for agricultural chemistry and medicinal chemistry as promising building blocks. The literature review containing 74 references describes approaches to synthesis of similar 1,2-azoles and use of these compounds. The literature data are classified according to the method of the corresponding heterocyclic system formation (according to the selection of strategic bonds) as well as by the mechanism of their formation (homolitic, heterolitic, synchronous). The approach to the synthesis of the heterocyclic system is shown to be strongly dependent upon the type of the heteroatom bonded to the nitrogen atom. Intramolecular cyclizations by different methods as well as intermolecular ways of8 producing similar 1,2-azoles are described in details.