Ohorodnik Y. Coordination compounds of Platinum(II), Palladium(II) and Ruthenium(II) bearing functionalized derivatives of 2-(1H-1,2,4-triazol-3-yl)pyridine.

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0823U100662

Thesis Registration Form

0823U100662.pdf

Applicant for

Specialization

  • 102 - Хімія

28-08-2023

Specialized Academic Board

1635

Taras Shevchenko National University of Kyiv

Essay

The thesis is devoted to the synthesis, characterization of the structure and physicochemical properties of the coordination compouns of Platinum (II), Palladium (II) and Ruthenium (II) with functionalized derivatives of 2-(1H-1,2,4- triazol-3-yl)pyridine. The complexes were constructed according to the cisplatinsimilarity principle (ie, “me-too” drugs) in order to improve the cytotoxicity of metal-based complexes. The substitution of two amine ligands for one diamino chelatic ligand was the first minor change. The central atom variation was the second type of cisplatin core modification. The synthesized compounds were fully characterized in solid state and in solutions. The antiproliferative properties in vitro of synthesized complexes were evaluated for five different cell lines. The first chapter of the work contains a review of the litreture, which highlights the characterization of new 1,2,4-triazole derivatives and platinum group metals. New trends in development of complexes of Platinum (II), Palladium (II) and Ruthenium (II) with N,N-bidental chelatic ligands were described, ie new Palladium (II) compound as catalysts for the C-C, C-N crosscoupling reactions and as new luminescent materials for their use as emitters in various devices. Nevertheless, the main motif of the first chapter is cytotoxic materials and the mechanism of their action. However, due to high general toxicity and the development of resistance of the cell lines towards platinum drug, investigation of cisplatin analogues is slill relevant.

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Research papers

Ohorodnik, Y. M.; Sikalov, A. A.; Khomenko, D. M.; Doroshchuk, R. O.; Raspertova, I. V.; Shova, S.; Babak, M. V.; Lampeka, R. D. Synthesis, structural characterization and anticancer properties of pcymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3- yl)pyridines. Transit. Met. Chem. 2022, 47(6), 213-221.

Khomenko, D. M.; Doroshchuk, R. O.; Ohorodnik, Y. M.; Ivanova, H.V.; Borys V. Zakharchenko, B. V.; Ilona V. Raspertova, I. V.; Oleksandr V. Vaschenko, O. V.; Alexey V. Dobrydnev, A. V.; Grygorenko, O. O.; Lampeka, R. D. Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles. Chem. heterocycl. 2022, 58(2/3), 116–128.

Khomenko, D.M.; Ohorodnik, Y. M.; Doroshchuk, R. O.; Raspertova, I. V.; Shova, S.; Babak, M. V.; Milunovic, M. N. M.; Lampeka, R. D., Synthesis, Characterization and Antiproliferative Activity of Platinum (II) Complexes with 3-(2-Pyridyl)-N1,2-Methyl-1,2,4-Triazoles.

Огороднік, Ю.; студ., Хоменко, Д.; Дорощук, Р.; Лампека, Р. Синтез етилових естерів 3-(2-піридил)-N-метил-1,2,4-триазол-5-іл оцтової кислоти та координаційних сполук Pd(II) на їх основі. Вісник Київського національного університету імені Тараса Шевченка. ХІМІЯ. 2017, 2(54), 40-42.

Огороднік, Ю.; Захарченко, Б.В.; Хоменко, Д.М.; Дорощук, Р.О.; Лампека Р.Д., Дослідження будови комплексу паладію (ІІ) на основі 3-(2-піридил)-5-циклопропіл-1,2,4-триазолу. Вісник Київського національного університету імені Тараса Шевченка. Хімія 2016, 1(51), 21-23.

Огороднік Ю. М., Хоменко Д. М., Дорощук Р. О, Лампека Р. Д. Синтез комплексів Pd(II) з функціоналізованими N-алкіл-1,2,4- триазолами. Міжнародна конференція студентів та аспірантів "Сучасні проблеми хімії" Збірка тез доповідей. – Київ, Україна. – 2017, 62.

Ohorodnik, Y. M.; Khomenko, D. M.; Doroshchuk, R. O.; Lampeka, R. D. Synthesis of Pd(II) complexes with functionalized N-alkyl-1,2,4- triazoles. IX International conference in chemistry Kyiv-Toulouse (ICKT-9). – Kyiv, Ukraine. – 2017, 95.

Огороднік Ю. М. Synthesis of Pt (II) complexes with functionalized n-alkyl-1,2,4-triazoles. V науково-практичної конференції школи молодих науковців ПАТ «Фармак» «НАУКА ТА СУЧАСНЕ ФАРМАЦЕВТИЧНЕ ВИРОБНИЦТВО». – Київ, Україна. – 2017.

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