BONDARENKO R. The Application of PRP Therapy in Atrophic Rhinitis

The dissertation explores the issues of diagnosis and treatment of patients with chronic atrophic rhinitis (CAR) and proposes methods for improving the functional outcomes of treatment for this disease by incorporating PRP therapy and quercetin according to the Unified Clinical Protocol (UCP). The aim of our study is to increase the treatment effectiveness of CAR patients by using PRP and quercetin. The author was the first to conduct a comparative evaluation of the effectiveness of CAR treatment under the UCP and an enhanced protocol that included the use of PRP therapy and quercetin in addition to the basic application of UCP. This is the first study that investigates the biochemical status of the nasal mucosa in CAR patients determining the indicators of NO-synthase forms (gNOS, cNOS, iNOS), arginase, L-oxiproline, H2S, MDA, and OMP, which has expanded the understanding of the pathogenetic mechanisms behind the disease's manifestation and determined their diagnostic value in treatment protocols. The author explored the dynamics of biochemical indicators in the nasal mucosa throughout the therapeutic process and correlated them with the clinical functional indicators of the upper respiratory tract during the application of different treatment methods for CAR. For the first time, the author has proposed introducing an additional application of PRP therapy in combination with quercetin into the UCP treatment of CAR, which increases the treatment’s clinical effectiveness. The study’s results are crucial for the further development of methods for treating and preventing recurrences of CAR. They provide a robust clinical-experimental basis for developing new, pathogenetically justified treatment methods for this condition. These scientific contributions are instrumental in planning future clinical studies seeking to evaluate therapeutic strategies' efficacy for CAR patients. Considering the expected improvements observed as a result of applying different treatment methods, further clinical studies can help to refine and optimize treatment protocols. Implementing our work’s findings into the curriculum at the Department of Otorhinolaryngology with Ophthalmology at Poltava State Medical University will contribute to the training of future doctors who will have access to modern research data and treatment methods for this disease. This is an important step in improving the quality of medical education and providing better care for patients with CAR. Keywords: rhinitis, atrophic rhinitis, platelet-rich autoplasm, PRP, quercetin, anosmia, acute rhinosinusitis, nasal cavity, mucous membrane, upper respiratory tract, nasal bleeding.