Chaban I. Cardiovascular risk and life quality of patients with a comorbid course of COVID-19 associated community-acquired pneumonia and arterial hypertension

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0824U003158

Applicant for

Specialization

  • 222 - Медицина

Specialized Academic Board

ДФ 58.601.148

Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine

Essay

The dissertation contains a new, scientifically based theoretical colligation and the solution of the topical task, which consisted in improving the algorithms for prognosis of the distant consequences of community-acquired pneumonia caused by COVID-19, associated with the comorbid course with arterial hypertension. For the first time in Ukraine, an analysis of laboratory data of the patients with the COVID-19 associated community-acquired pneumonia and arterial hypertension depending on the severity of pneumonia and the cardiovascular risk degree has been carried out, and associative links with the quality of life 1 year after hospital discharge have been established. It was determined that the comorbid course of COVID-19 associated community-acquired pneumonia and arterial hypertension is accompanied by a high and very high cardiovascular risk independent of the severity of pneumonia due to age, comorbid heart failure and peripheral vascular disease, while patients without concomitant arterial hypertension were diagnosed with a moderate cardiovascular risk. It has been proven that the numbers of erythrocytes, ESR, leukocytes, ALT and AST, LDL-C, triacylglycerols (TG), CRP, procalcitonin, and ferritin are likely to be higher with the increasing of severity of COVID-19-associated community-acquired pneumonia and the degree of cardiovascular risk. It has been shown that the poor life quality of the patients with the community-acquired pneumonia associated with COVID-19 1 year after hospital discharge is affected by older age (increases the risk of the physical component by 7.20 times and the psychological component – by 2.90 times), heart failure (increases the risk by 9.63 and 3.97 times, respectively), peripheral vascular diseases (increases the risk by 7.26 and 2.95 times, respectively). It has been proven that the patients with a comorbid course of pneumonia and hypertension probably have lower values of life quality compared to the corresponding data in the patients without hypertension. For the first time, it has been shown that 1 year after experiencing community-acquired pneumonia associated with COVID-19, a higher degree of cardiovascular risk negatively affects the physical and psychological components of health. It has been determined that the general blood test (hemoglobin, ESR, and leukocyte level), acute phase indicators (CRP, procalcitonin and ferritin), aminotransferase activity, and lipid profile data in the acute period of community-acquired pneumonia associated with COVID-19 were connected with life quality 1 year after hospital discharge.

Research papers

1. Чабан ІВ, Марущак МІ. Аналіз коморбідної захворюваності при негоспітальній пневмонії, асоційованій з COVID-19. Вісник проблем біології і медицини. 2024;2(173):288-94. DOI: 10.29254/2077-4214-2024-2-173-288-294.

2. Чабан ІВ, Марущак МІ. Особливості показників загального аналізу крові при коморбідному перебігу негоспітальної пневмонії, асоційованої з COVID-19 та артеріальної гіпертензії. Медична та клінічна хімія. 2024;26(2):33-40. DOI: 10.11603/mcch.2410-681X.2024.i2.14765.

3. Чабан ІВ, Губенко ІЯ. Аналіз компонентів кардіоваскулярного ризику при коморбідному перебігу негоспітальної пневмонії, асоційованої з COVID-19 та артеріальної гіпертензії. Health & Education. 2024;2:102-10. DOI: 10.32782/health-2024.2.13

4. Чабан ІВ, Марущак МІ. Якість життя хворих на негоспітальну пневмонію, асоційовану з COVID-19 та коморбідну артеріальну гіпертензію з різним кардіоваскулярним ризиком. Перспективи та інновації науки. 2024;7(41):1197-214. DOI: 10.52058/2786-4952-2024-7(41)-1197-1214.

5. Марущак МІ, Чабан ІВ, Мялюк ОП, Демянчук МР, Вольська АС. COVID-19 та серцево-судинні захворювання: особливості коморбідного перебігу. Health & Education. 2024;2:49-61. DOI: 10.32782/health-2024.2.8

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