Malkovych N. Peculiarities of the clinic and course of osteoarthrosis in patients with accompanying diseases of the gastroduodenal and hepatobiliary systems and the pathogenetic ways of their correction

The thesis is dedicated to a study of the peculiarities of lesions of the gastroduodenal and hepatobiliary systems in patients with OA. Their connection with the form, the stage of the primary disease and secretory function of stomach and gall- bladder was found. The increase of products of peroxide oxida- tion of lipids and the relaxation of the activity of glutathyon an- tioxidant system were revealed in the blood, what was accompa- ned by the increase of the concentration of syalic acids. The use of bee pollen in the multimodality treatment proved to have a positive effect on the course of OA, on gastro-, hepatopro- tective and antioxidant properties and in the experiment it has a positive effect on the morphologic state of rheumatic gristle, ga- stroduodenal mucosa and liver tissue. oxidation of lipids, glutatyon antioxidant system, bee pollen The thesis is dedicated to a study of the peculiarities of lesions of the gastroduodenal and hepatobiliary systems in patients with OA. Their connection with the form, the stage of the primary disease and secretory function of stomach and gall- bladder was found. The increase of products of peroxide oxida- tion of lipids and the relaxation of the activity of glutathyon an- tioxidant system were revealed in the blood, what was accompa- ned by the increase of the concentration of syalic acids. The use of bee pollen in the multimodality treatment proved to have a positive effect on the course of OA, on gastro-, hepatopro- tective and antioxidant properties and in the experiment it has a positive effect on the morphologic state of rheumatic gristle, ga- stroduodenal mucosa and liver tissue. Key words: osteo-arth- rosis, gastroduodenal system, hepatobiliary system, peroxide. oxidation of lipids, glutatyon antioxidant system, bee pollen