Trunov G. Optimization of treatment locally advanced lung cancer

The thesis is dedicated to questions of effectiveness of diagnosis and combined treatment of locally advanced lung cancer. Combined use of roentgenography, computer tomography and fibrobronhoscope enables to increase preoperative diagnosis of locally advanced lung cancer to 83,1% cases in comparison with 70,9% cases of standard roentgenography. While studying neuropeptide of the blood it was found out that the level of blood bombesine in 37,5 % of patients was in 4 times more than in control. 83,3 % of these patients included those with poorly differentiated cancer or non-small-cell lung cancer. A new method of regional resection of the left atrium during combined pneumonectomy as a result of locally advanced lung cancer was developed. It was proved the effectiveness of adjuvant chemo-radiotherapy of patients with locally advanced lung cancer with invasion of lymph nodes of mediastinum