Topol'nikova N. Influence of ionizing irradiation on glycocorticoid function of adrenal glands of rats of different age

Thesis devoted investigation of age-associated peculiarities of the changed in some indices, characterising glycocorticoid function of adrenal glands under single and chronic exposure of ionizing irradiation in broad spectrum of doses and time of irradiation. It is established that after single roentgen irradiation the changes of considered indices of glycocorticoid function of adrenal glands in the early and later stages in most cases are more pronounced in adult animals as compared to the old ones. It was the first time that the relationship between the level of polarization of plasma membrane and intensity of secretion of glucocorticoids by isolated adrenal glands under condition of single and chronic ionizing irradiation. It was discovered that activation of lipid peroxidation in adrenal glands tissue could be one of the possible causes for decrease of spongiocyte membrane potential under exposure to ionizing irradiation. Age-associated features of adaptive reactions on combined action of chronic i onizing irradiation and chronic situation stress were investigated The possibility to prevention and mitigation of the violation of glycocorticoid function of adrenal glands, caused by ionizing irradiation by prepation of blue-green seaweed Spirulina platensis and normobaric hypoxic training were established.