Chebanov V. Heterocyclisation reactions on a base of diaminopyrimidine derivatives and a,b-unsaturated carbonyl compounds

The present thesis is devoted to the study of an interaction of some pyrimidine ortho-diamines with carbonyl compounds, an influence of substitutes on a way of the reaction and a stability, physico-chemical and chemical properties of substances synthesized. A new direction of heterocyclisation of 1,3-dimethyl- 5,6-diaminouracil with aromatic and cyclic unsaturated ketones, which yielded 1,7,9-triazaspiro[4,5]dec-1-ene-6,8,10-triones was established. A decrease of solubility of the diamines when protoncontaining substitutes were put at 2-position of pyrimidine cycle decreased the reactivity in respect of a,b-unsaturated ketones and their derivatives. A tautomerizm of pyrimido-1,5-diazepines and analisys detailed of chemical and physico-chemical properties of pteridinoles were studied too.