Lyudvik T. Clinical-immunological characteristics and improvement of treatment in patients with children juvenile rheumatoid arthritis.

There are represented study concerning clinical period of JRA in child age. The evidence of expressed intoxication, pain syndromes, the presence of progressive inflammative - destructive disorders in joints are proved. The increase of anti- inflammative mediator TNF-a and it's soluble receptors as well as circulating immune complexes is presented in blood serum within active period of disease. The disorders of cell immunity are characterized by lymphopenia on the background of leucocytosis, increase of CD3+CD4+ cells helpers-inductors levels and activated T-cells, which expressed molecule HLA-DR on their surface, increase of CD3+CD4+/ CD3+CD8+ cells correlation, reduction of CD3-/CD16,56+ cells natural killers. The hypocalcemia, reduction of organism supplement by vitamin D3 are being represented. The expediency of JRA complex pharmacotherapy improvement by means of enterosorbtion inclusion using sorbent with non-specific activity "Enterosgel" is backgrounded. The method of enterosorbent prescripti on is proposed. It'd been proved that including enterosorption in treatment of children with JRA promoted the health state of patients, reduction of disease manifestation and reverse development of some symptoms, led to more expressed changes in immunity and stabilization of calcic-phosphoric homeostasis comparatively to routine protocols.