Prokopiv O. Clinical and prognostic significance of local immune disturbances in salmonellosis in early childhood and the possibility of their correction

On the basis of clinical and laboratory studies of 146 children of early age having salmonellosis, determining the severity level and the variant of the course of the disease by cytoprotective ability of the mucous membrane of the intestines, it being provided with local action immunoglobulins and phagocytic system of neutrophils defence, has been proved for the first time.It has been stated that immunoglobulins of the local action contribute to the localization of acute intestinal inflammatory process and prevend extraintestinal translocation of the causative agents of monosalmonellosis and associeted forms of the disease. . Among indices of indication complex of disturbances of phagocytic activity of neutrophils predominate the following: neutropenia, low indices of phagocytes number, significant and stable lowering of the content of cation proteins in neutrophils. It has been stated that enterosorbent sillard-P, besides its detoxicational and a tidiarrheal effect, influences positively local mechani sms of immunological defensе.