Shakhnin D. Phosphonium Derivatives of Pyrimidine Bases in Synthesis of Acyclic Nucleosides Analogues

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U000694

Thesis Registration Form

0400U000694.pdf

Applicant for

Shakhnin Dmytro Borysovych

Specialization

02.00.10 - Біоорганічна хімія

Date of defense

10-03-2000

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

The dissertation is devoted to elaboration of original strategy for synthesis of novel acyclonucleosides types based on phosphonium derivatives of pyrimidine bases The convenient preparative syntheses of C5-phosphorylated 4,6-difunctionalized pyrimidines, in particular, some new types of phosphonium ylides of pyrimidine series were elaborated. Alkylation of 2-alkyl(aryl)-4-hydroxy-6-mercapto-pyrimidines 5-phosphonium derivatives was found to be of particular importance because of its high regioselectivity. Phosphonium synthesis of acyclonucleosides is a valuable addition to conventional approaches to these important bioregulators obtaining.

Thesis supervisor

Драч Б.С.

Official opponents

Вовк А.І.
Толмачов А.О.

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