Garazd M. Synthesis and properties of modified neoflavones and 3-phenoxychromones

The thesis is devoted to the synthesis of modified analogues of natural 3-phenoxy-chromones and 4-phenylcoumarins with resorcinol, phloroglucinol, pyrogallol and orcinol orientation of hydroxy groups. With the purpose to receipt of new physiologically active substances on the basis of 3-phenoxychromones and neoflavones and to study of their chemical properties the reactions of acylation, alkylation and arylation on phenolic group, Mannich reaction, reactions with participation of carbonyl group of chromone's cycle, additional building-up of dihydrooxazine and furan cycle on corresponding positions of coumarin's system were carried out, and also various aminoacid's and peptide's derivatives of 3-phenoxychromones and neoflavones were synthesized.