Andronati K. Synthesis, structure and properties of 3-hydroxy- and 3-acyloxy-1,2-dihydro-3H-1,4-benzodiazepine-2-ones

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U000824

Thesis Registration Form

0400U000824.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

31-03-2000

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

5-Aryl-3-hydroxy- and 3-acyloxy-1,2-dihydro-3H-1,4-benzodiazepine-2-ones were synthesized. Inclusion compounds of 3-hydroxybenzodiazepinones with benzene and cinazepam with ?-cyclodextrine were obtained and their structure was established. Acid hydrolysis of 3-acyloxybenzodiazepinones was studied. 3-Hydroxyphenazepam and 1-methylhydroxyphenazepam possess the highest affinity to benzodiazepine receptors. They are also the most active anxyolitics and anticonvulsants. Cinazepam is the most selective anxyolytic and anticonvulsant. Bioorganic chemistry, medicine, pharmacology.

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