Konyushevs'ka A. Clinical features of the course and improvement of complex therapy of acute glomerulonephritis in children with signs of connective tissue dysplasia.

123 patients, aged twelve montus to 15 years wirh various forms of glomerulonephritis, living in the Donetsk industrial region were studied. 40 practically healthy children made up a control group. Antioxidants: vitamine E, essentiales and their complexes were employed in 91 children to correct impairments in the peroxidization system of lipid and in an antioxidant protection in acute glomerulonephritis. 25 children did not receive antioxidants and were as controls. The aim of the study is to enhance the efficacy of acute glomerulonephritis complex therapy in children taking into considerations the specific features of the condition of the child?s connective tissue, the system of lipid peroxidization and an antioxidant protection by utilizing the means contributing to normalization of peroxidization processes in the organism. The methods of studying: clinical, biochemical, immunological, instrumental. Apparatuses: spectrophotometer, chemiluminometer, ultrasonic study device, photo electrocalorimeter. Theoretical and practical significance. An increase in severe forms of acute glomerulonephritis in children of the Donetsk industrial region has been shown. The presence of connective tissue dysplasia has been proved to unfavourably infllience the course of acute glomeruloonephritis. That is why the stigmas of connective tissues dysplasia and dysembryogenesis can be one of the criteria of disease course severity prognosis. The standards of lipid peroxidization values and those of antioxidant protection in healthy children, aged 1-15 years, living in the Donetsk region have been developed. Diagnostic significance of the lipid peroxidization values and that of antioxidant protection as a criterion of the process activity and control of treatment efficacy of acute glomerulonephritis has been proved. Expediencu of antіoxіdant administration in acute glomerulonephritis in children has been grounded pathogenically, the designs of their application in various form of acute glomerulonephritis in children for the treatment and prophylaxis of disease relapses have been developed. The results of the study have been introduced in the children's hospitals and in the somatic departments of the citi hospitals of Donetsk, Mariupol, Makeyevka, Ugledar. The field of application - pediatrics.