Bondar L. Transplantation of the embrionic nervous tissue in the treatment of brain ischemia in the experiment

The perspective direction of the utilisation of the method of transplantation of the embryonic nervous tissue (TENT) in the clinical practice is restricted by the insufficient investigation of the mechanisms of the medicinal influence of the implanted tissue on the damaged brain of the recipient. This experimental work represents an investigation of the influence of the TENT on the restoration of the structural-morphological damage of the neurocytes, which were in the condition of ischemic stroke.The elaboration and introduction of a new model of hemisphere ischemic stroke of rats conditioned the success of the work; it differs greatly from all existing models. We consider the simplicity and absence of the side effects of the modelling to be the advantages of this model. This was the condition of the purity of the results of the experimental investigation. The revealed dynamics of the recovery of the dystrophic damaged after ischemia stroke cellular elements testimony to the more quick and full regress of the pathological changes of the neurocytes in the case of application of the ENT as means of the treatment. At the same time it should be mentioned that, although TENT slows down, but it doesn't prevent the development of the glyoz in the centre of the ischemic damage of the cerebrum. Positive influence of the application of the ENT on the normalisation of the structural-morphological damage of the cellular organelles (mitochondria, nuclear chromatin) was fixed on the electronic-microscopic level, what shows improvement of the energy-productive and protein-integrative function of the neurocytes. However, during the investigation of the therapeutic effects of the TENT on the dynamics of the recovery of the ischemicaly damaged synaptic apparatus it was established that inspite of the practically full restoration of the length of the synaptic fissure, the number of the synaptic vesicles is much less than the norm. This can explain the insufficient functioning of the cerebral tissue, which suffered from the is chemic stroke