Yarynkina O. The 24 hour blood pressure variation and neurohumoral aspects of its regulation in the morning hours at the essential hypertensive patients

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U001255

Thesis Registration Form

0400U001255.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

25-04-2000

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The dissertation is devoted to the study of the influence of different factors, that support blood pressure(BP) level, on its increase in the morning and of the antihypertensive therapy influence on these factors at the essential hypertensive patients. The BP incremernt in the morning hours (from 6 to 9 a.m.) was associated with significant increase of vasoactve factors levels. BP increment and the rate of BP rise dropped significantly at losartan and amlodipine therapy. Lowering of BP increment in the morning under amlodipine course was associated with plasma norepinephrine, epinephrine and Ca2+in level decrease. Both losartan and amlodipine normalized fasting insulin level in the morning.

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