Tytova T. Content of phosphoinositides and activity of carboxypeptidasa-N characteristic of patient suffering from nephrogenic hypertension in treatment dynamics

The work presents clinicobiochimic characteristics of 138 patients with nephrogenic hypertension and hypertension disease. Investigated is the relation of changes in the exchange between secondary messengers of calcium ions (phosphoinositides) with disturbances in carboxypeptidasa system for patients suffering from nephrogenic hypertension. It is established that in the case of nephrogenic hypertension, changes take place in the proportion of phosphoinositides with prevailing increase of the content of phosphoinositide triphosphate. Found is a disturbance in the processes of calcium transfer at kidney hyperfiltration, as well as a positive effect of APF virphene inhibitor on the system of secondary messengers and the content of carboxypeptidasa-N in the dynamics of treatment of such patients. Developed are metabolism disturbance criteria for secondary messengers (phosphoinositides) in the case of hyperfiltration for patients suffering from inflammatory kidney diseases. Such criteria allow to realize di fferential treatment taking into account individual sensitivity to utilized medicines. An estimation is made for the influence of piavite on the indexes of plasma and thrombocyte hemostasis. It is found that for patients suffering from nephrogenic hypertension the use of this preparation yields a positive dynamics of arterial tension and a decrease of carboxypeptidasa-N activity. The positive effect ofplasmapheresis for the said patients is caused not only by a decrease ofpressor hormones in blood plasma, but also by its positive influence on the calcium transfer system of secondary messengers and hemostasis system indexes.