Tsykalov V. Synthesis and biological activity of glycosides of muramyldipeptide

Object of investigation: muramylpeptides, a- and b-glycosides of muramyldipeptides. Aim of investigation: sinthesis new glycosides of muramyldipeptides distinguishing by structure of aglycone and configuration of glycoside binding and also determination of influence of the structure glycosides of MDP for biological activity. Methods of investigation and instruments: organic synthesis, NMR-spectroscopy. Theoretical results and novelty: the sinthesis of new b-glycosides of MDP with aglycones of aliphatic, cycloaliphatic and aromatic nature and also a-glycosides MDP was devised. High biological activity of b-alkil- and b-cycloalkilglycosides MDP was fixed; it has shown that a-glycosides muramyldipeptides yield to immunostimulant activity both corresponding b-glycosides and MDP. Practical results and novelty: New glycosides of MDP with aglycones of different structures and configuration of glycoside link were sinthesized. Sinthesized substances may be used as immunostimulants and stimulants of antiinfectio nsresistance. Subject and degree of introduction: application of present work results in scientific and education practice in universities and institutes of Ukraine. Efficiency of inculcation caused due to the more perfect synthesis methods glycosides of MDP and more active derivative muramyldipeptides. Field of application: chemistry, medicine.