Kharkhun M. The characterization of voltage-gated ionic currents of mesenteric artery myocytes membrane from genetically hypertensive rats.

3. The dissertation is devoted to pharmacological and biophysical studies of ionic currents of myocytes from resistance mesenteric arteries normotensive and genetically hypertensive rats. It was found that 4-AP-sensitive component of outward current was smaller in the myocytes from hypertensive rats. SMCs of normotensive rats had a mean resting potential of -38 mV and depolarized by 4-AP (5 mM), but not by TEA (1 and 10 mM). The density of inward current was significantly increased in resistance mesenteric arteries from hypertensive rats. The steady-state inactivation curve of IBa was shifted 3 mV positively in hypertensive animals. The amplitude of the window current was increased in myocytes from hypertensive rats.