Ryzhenko S. Efficiency of probiotocs on a bassis of aerococci in struggle with purulent - inflamatory diseases

The dissertation is devoted to an estimation of efficiency new probiotics from aerococci, products of their ability to live and synergic chemo-therapeutic preparations in struggle with purulent - inflammatory diseases. The levels of production of hydrogen peroxide by different species of aerococci are established and the degree of its antagonistic influence on microorganisms induced purulently - inflammatory processes is determined depending on conditions of cultivation. The selection chemo-therapeutic preparations is carried out and their optimum dozes raising antagonistic action of aerococci concerning microorganisms induced purulent - inflammatory processes are determined. The degree of production by aerococci antagonistic substances of a not oxidizing nature is determined, the methods of their allocation, division and identification are developed. Efficiency antagonistic activity of substances of a not oxidizing nature on models of experimental infections at an animal is established. The sensit ivity to antibiotics, A-bacterinum and complex (A-bacterinum, KJ, ethonium) at 88 species of candids, allocated at the patients with candidosis of different localization was investigated. Is established, that the greatest antagonistic action on candids renders a complex (A-bacterinum, KJ, ethonium). The efficiency of a complex was confirmed at treatment of urogenous candidosis at 15 women.