Orlenko V. Condition of joint-skeletal system in patients with diabetes mellitus.

Object of research: diabetic arthropathy and osteoporosis associated with diabetes mellitus (DM). The purpose: to study clinical peculiarities of manifestations and develop- ment mechanisms of complications in joint-skeletal system in patients with DM. Methods and apparatus: clinical, bio- chemical, instrumental; ultrasound densitometry, photocalo- rimetre, computer. Theoretical and practical outcomes: it was established that joint lesions in patients with DM have degenerative-dystrophic character with metabolic disorders in total glycosaminoglycans. System disorders in the bone tissue with density decrease and elasticity changes of its structure are characteristic for patients with DM. Innova- tion: some differences in development mechanisms of os- teopenias in type 1 and 2 DM are established and diagnostic methods of diabetic arthropathias and osteopenias are based. Degree of introduction: results of investigations and diag- nostic methods are introduced into the work of the Depart- ment of Endocrinology, the data obtained are used in courses of lectures in the medical Institutions. The sphere of use: endocrinology, orthopedics.