Reznichenko I. The substantiation of place and effectiveness of H2-receptor blockers in modern out-paient pharmacotherapy of duodenal (peptic) ulcer.

The disertation is devoted to substantiation of the criteria of differentiated prescription of H2-receptor blockers for patients with duodenal (peptic) ulcer according to the data of computer-aimed pH-metry. There is established that the criteria of differentiated prescription of H2-receptor blockers for patients with duodenal (peptic) ulcer are the presence of individual maximum of intragastric acidity,entering the functional interval pH 5 or 4, especialle when dissemination of functional interval pH within of the stomach does not exeed 75%, and the presence of satisfactory sensitiveness to H2-receptor blockers. We investigated the effectiveness of complex out-paient treatment with H2-receptor blocker famotidine and standard triple therapy for the eradication of H.pylori in patients with duodenal (peptic) ulcer. The data of this investigation confirm the conclusion, that by taking famotidine the optimal level of the intragastric pH for manifestation of maximum activity of antibiotics and the eradica tion rate of 89,47 - 94,12% are achieved.