Plyatsko M. Influence of antiulcer preparations on the aggressive and protective factors in the patients with duodenal ulcer

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001540

Thesis Registration Form

0401U001540.pdf

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

08-05-2001

Specialized Academic Board

Д20.601.01

Essay

There were examined 159 patients with duodenal ulcers with the aim of investigation the influence of H2-blockers and prokinetics on the aggressive and protective factors by the histamin-blockers tests and ground the methods of increasing the effectiveness of treatment with this preparations. It was establish, the positive influence of H2-blockers on cytoprotective mechanisms and relationship with K+ concentration and acid inhibition, also the prokinetic influences on the aggressive factors in the main by decreasing of acid and pepsin debit. Experimental proofs and further confirmed in clinical settings that famotidin and metoclopramide administered simultaneously decreased acid and, especially, pepsin secretion. The results of the investigation permits an individual choise of preparations for treatment of ulcer disease with taking into consideration the effects of aggressive factors and citoprotective mechanisms.The field of application - medicine.

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