Kocheshev I. Synthesis and study of physics-chemical properties of homo-n-mer monomethyne cyanine dyes - highly efficient fluorescent probes for nucleic acids detection

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001585

Thesis Registration Form

0401U001585.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

25-05-2001

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

Homo-n-mer monomethyne cyanine dyes. Synthesis of new cyanine dyes and investigating of their interaction with nucleic acids. Chemical synthesis and spectral researches. Are synthesized 12 new fluorescent cyanines , for the first time are received homotrimeric dyes, are investigated their spectral-luminescent properties at presence NA. It was shown, that the presence of aggregation processes considerably increases sensitivity of detection of DNA. Is offered sandvich model of aggregation structures of dyes. Is shown, that they can be used as fluorescent probes for definition NA. Bioorganic chemistry, molecular biology.

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