Yakovishyn L. Triterpene glycosides of Canarian ivy Hedera canariensis Willd.

Object of investigation: Canarian ivy Hedera canariensis Willd. Subject of investigation: triterpene glycosides, their haemolytic and ichthyotoxic activities. Aim of investigation: the isolation and complete structural elucidation of triterpene glycosides from Canarian ivy and determination of connection between the biologic activities with their structures. Methods of investigation: chromatographic methods, acid and alkaline hydrolysis, ammonolys, methylation with diazomethane, 1H- and 13C-NMR-spectroscopy and photometry. Theoretical and practical results and novelty: triterpene glycosides from different organs of Canarian ivy were isolated for the first time and their complete structures were determined. Among 40 isolated glycosides, 8 are the new compounds. Glycosides of 30-nor-hederagenin and caulophyllogenin were found in the Hedera genus and Araliaceae family for the first time. A connection between the cytotoxic activities of glycosides with aglycons' and carbohydrate moieties' structures was e stablished. Results may be used as for development of Hedera genus systematic, for creation drugs and for search of the new immunoadjuvants with low cytotoxic activity. Field of application: chemistry, immunochemistry, medicine, chemosystematic.