Krotenko O. Changes of a lipid metabolism in patients with unstable angina on a background Coxsackie B virus infection and their therapeutic correction.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001808

Thesis Registration Form

0401U001808.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

12-06-2001

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The thesis is dedicated to investigate the pathogenetic link between cardiotropic viruses Coxsackie B and unstable angina from the aspect of lipid modulation. It was demonstrated, that association of viruses, promote the development of unstable angina at a younger age, burdening clinical characteristics of a disease, with the increased frequency of myocardial infarction. In patients with unstable angina, Coxsackie B viruses induce, changes in the lipid spectrum in blood serum, erythrocyte membranes, lipoproteins. Were demonstrated the necessery of the pathogenetic correction and efficiency of the Tekom high in ?-3 PUFA: reduced the free cholesterol level in erythrocytic membranes, increased level ?-3 PUFA -a predecessor eicosanoids with vasodilatation and antithrombotic effects.

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