Volyans'kyj A. Antimicrobial effect of metin's derivates of quindinium and mathematical modeling of biologically active compounds screening.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U003100

Thesis Registration Form

0401U003100.pdf

Applicant for

Specialization

  • 03.00.07 - Мікробіологія

15-11-2001

Specialized Academic Board

Д 26.003.01

Essay

Thesis is devoted to the problem assotiated with the search of a new antimicrobial compounds among quinolinum metin derivates. Antimicrobial activity of 92 new chemical compounds relative to pathogens, which cause infectious and suppurative inflammatory diseases, have been studied. Toxity, cumulative, irritating and allergic effects induced by the most active compounds are inverstigated. Dependence of antimicrobial activity and toxity on chemical structure of quinolinium derivatives has been analysed, which allow to perform a forecast for synthesizing compounds with predetermined properties.

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