Lisovs'kyj I. Expression of defensin genes in the cells of human malignant tumors.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U001345

Applicant for

Specialization

  • 14.01.07 - Онкологія

10-04-2002

Specialized Academic Board

Д 26.155.01

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Essay

The defensin genes expression spectra in malignantly transformed human cells of different histogenesis has been established. It was demonstrated that in A431 and M-HeLa cells hBD-2 gene expression is induced upon challenge of growth factors. It is shown that hBD-2 production inhibits the phosphokinase activity of epidermal growth factor receptor.

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