Kolesova N. Peculiarities of alteration and reparative regeneration of gum epithelium in generalized periodontitis and their pharmacological correction.

The dissertation is devoted to treatment efficacy enhancement of generalized peridontitis due to the elucidation of both peculiarities of gum epithelium alterations and regeneration and purposeful pharmacological correction. A correlation of clinical symptoms with methabolical and structural features of gum epithelium barrier function deterioration along with reparation completion level was revealed in 111 patients with generalized periodontitis using clinical, laboratory and pathomorphological (morphology, hystochemistry and electron-microscopy) methods. It is shown that in the course of chronic inflammatory and destructive process in periodontal tissues in generalized periodontitis, it is feasible to distinct a postclinical stage in addition to commonly used preclinical and clinical manifestation stages. Clinical, laboratory and morphological features of this stage are determined. It was elucidated that after course of antiinflammatory treatment, alterations of gum epithelium regeneration manifest in hypoxy and energetic disturbances that preclude further development of cell differentiation. This is a prerequisite for both development of insufficiency of gum epithelium barrier function and reduction of the disease remission. It is ascertained that a targeted pharmacological correction is needed at the postclinical stage of generalized peridontitis. Methabolic-type drugs rendering antihypoxy action are expedient. Mildronat is a representative of this group of drugs, possessing of a cell-protective action. Complex treatment leads to the enhancement of both periodontal tissues and gum epithelium regeneration