Ignatov V. Pathogenic role of proinflammatory and profibrogenic cytokines in the formation of fibrosis reactions at chronic hepatitis

The research is devoted to the determination of the pathogenic role of interleukin-6, alpha-tumor necrosis factor, granulocyte-macrophagal colony-stimulating factor and transforming growth factor-1в cytokines in the formation of fibrosis in the liver of patients ill with chronic alcoholic hepatitis at the low inflammation activity degree. It has been established that there is a direct connection between an increased content of the alpha-tumor necrosis factor, clinical manifestations and biochemical inflammation activity markers - alanine aminotranspherase, lipid peroxide oxidation process activation, and antioxidant protection depression. Increased levels of protein-connected hydrooxyproline and morphological signs of a more active collagenogenesis corresponded to the increase in the granulocyte-macrophagal colony-stimulating factor and the transforming growth factor-1в. General principles have been identified in the character of changes in the studied cytokines, biochemical and morphological inflammation markers and fibrosis with regard to the patients ill with chronic alcoholic hepatitis. After a 6-month treatment with Essentiale H, patients ill with chronic alcoholic hepatitis have shown an increase in interleukin-6 and a decrease in alpha-tumor necrosis factor, granulocyte-macrophagal colony-stimulating factor and transforming growth factor-1в. This was accompanied by a disappearance or a decrease in the major clinical symptoms, a decrease in the level of hematologic inflammation and collagen formation markers, and a decrease in the morphologic signs of collagenogenesis.